Itchy skin with fever is considered to be due to poor resistance of the patient with fever, low local skin defense function, easy metamorphosis of skin tissue with endogenous and exogenous allergens and allergic symptoms. Therefore, oral anti-allergic drugs can be used to treat the symptoms, such as paracetamol and cetirizine. In addition, patients with fever can also suffer from allergic symptoms after taking oral antibacterial or antiviral drugs, and they can develop itchy skin. Therefore, patients with fever should also be encouraged to drink more water and rest to enhance drug metabolism in order to reduce the occurrence of itchy skin, and the symptoms of fever and itchy skin will be improved with the effective drug treatment.