After prosthetic valve replacement for heart valve disease, warfarin anticoagulation is required for life because of the tendency for blood clots to form on the valve. However, if the dosage is high, it can cause internal bleeding (severe bleeding in the brain) and other complications, so the dosage of warfarin needs to be controlled and reviewed for a long time. Generally, the INR (International Standard Ratio) is controlled between 1.8 and 2.2 after rechecking the prothrombin time (PT test). (Subject to mitral valve replacement, aortic valve replacement can be appropriately low, 1.6 to 2.0, double valve replacement basic Ann mitral valve replacement prevails or slightly higher.) 1, the formal review advocates a review of 3 days after discharge, 3 consecutive reviews qualified. Can be changed to 1 week 1 time, and then 3 consecutive qualified can be changed to half a month 1 time, after 3 consecutive qualified changed to 1 month 1 time, at least 3 months review 1 time, that is, even very smooth should be 1 year review 4 times. We believe that if the conditions do not allow it, we can first check once in 5-7 days, change to once in half a month after 2-3 times, and then transition to once in 1 month, and then eventually it is better to check once in 3 months after normal. However, if the test results are seriously off the target should start from the beginning (i.e., from 5-7 days to check once). Of course, the initial adjustment of the amount of diligence, such as 3 days to check once or even once a day will be more secure. 2, our hospital warfarin for imported Finnish production warfarin, due to the dose, the active ingredient is different, the above checks and so on should be based on the patient’s own long-term oral warfarin. (It is best to fix the manufacturer, fixed brand of warfarin to facilitate the adjustment of the dose) (for example, in the local hospital oral warfarin may be taken in doses that differ significantly from our hospital, but the INR value of the final control shall prevail). 3, if the INR value > 3, it is recommended to immediately stop taking the drug for 3 days, and then reduce the dose; if < 1.5 recommended to increase the dose appropriately, the standard of increase or decrease to a quarter of a tablet shall prevail (to our hospital drug shall prevail), avoid a larger increase or decrease in drug dose. 4, dietary issues: eat less spinach, fava beans, specifically in the usual record of the small white book with detailed instructions, please read carefully; and whether taking certain foods can cause changes in the coagulation mechanism, you can promptly review PT to understand the situation.