Normal results of coagulation quadruple test can preliminarily exclude thrombophilia and coagulation system diseases, but the specific needs to be combined with other related test results. Coagulation four tests include prothrombin time, prothrombinogen time, partially activated prothrombin time and fibrinogen. They are clinically used to observe the coagulation function status in the body. If the test result is normal, hemophilia, disseminated intravascular coagulation, vitamin deficiency, severe liver disease (cirrhosis, severe hepatitis, etc.), thrombosis and other coagulation pathologies can be initially excluded. As a mandatory preoperative coagulation test, it can assess whether the patient has any problems with coagulation and hemostasis, and relative measures can be taken before the operation to avoid the occurrence of intraoperative hemorrhage. If the results of coagulation quadruple test are normal, refer to other related tests, and if there is any abnormality, consult a doctor in time to clarify the cause of the disease with the help of the doctor, and carry out targeted treatment or therapy.