When creatinine is 160 μmol/L, it may be caused by physiological factors, such as eating a lot of meat, muscular athletes, etc., at this time it is a normal phenomenon, not renal failure; or it may be renal failure, common causes such as gastrointestinal hemorrhage, chronic glomerulonephritis and so on. Blood creatinine is the product of glomerular filtration and excretion, which can reflect the glomerular filtration rate to some extent and evaluate the glomerular filtration function. Various reasons can lead to the decline of renal function. However, clinically, blood creatinine is not generally used as the basis for diagnosing kidney disease, because the human kidney has a relatively strong compensatory ability, so blood creatinine can not be used as a separate indicator to determine early renal insufficiency, because the indicator affects a lot of factors, such as activity level, muscle mass, diet and so on. Therefore, creatinine alone cannot be used as an indicator of early renal insufficiency because it is affected by many factors, such as activity level, muscle content, diet and so on. A creatinine of 160 μmol/L may be normal, such as patients with physiologic elevation (muscular athletes, eating a lot of meat food, etc.); or it may be renal failure, such as a decrease in glomerular filtration rate caused by various acute and chronic factors, such as gastrointestinal bleeding, drug-induced renal injury, chronic glomerulonephritis, and diabetic nephropathy. When creatinine is 160μmol/L, it is recommended to seek medical treatment in regular hospitals in time to make a clear diagnosis and standardize the treatment under the guidance of professional doctors.