Disadvantages of endocrine therapy for breast cancer include limited scope of application, influence of treatment effect on hormone receptors, longer treatment time and certain side effects. 1. Limited scope of application: endocrine therapy for breast cancer is only applicable to some breast cancers, including estrogen receptor and progesterone receptor breast cancers, and it cannot be used for those who do not express hormone receptors. 2. Treatment effect is affected by hormone receptor: for breast cancer with high expression rate of hormone receptor, the treatment effect of this method is better, but if the expression rate is lower, the treatment effect is worse. 3. Longer treatment time: the treatment of breast cancer should last for at least 5 years, and some of them will last for more than 10 years or even longer. 4. Certain side effects: it may cause menstrual disorders, or abnormal proliferation of endometrium, or even the occurrence of endometrial cancer. It can be seen that breast endocrine therapy has the above mentioned disadvantages, and one should follow the doctor’s instructions for breast cancer endocrine therapy and consult the doctor in time when there is any discomfort.