Over the past 20 years, considerable progress has been made in the field of research on the causes of Parkinson’s disease. However, to date, the etiology of Parkinson’s disease remains unclear. Current research favors a combination of factors related to ageing, environmental factors and genetic factors. The following is a brief description of this aspect. 1, ageing: the prevalence increases gradually with age, a fact that supports the claim that ageing factors, such as the prevalence of people over 55 years of age is 1%, and over 65 years of age is about 2%. Dopaminergic neurons decrease with age. When dopaminergic neurons decrease by 50% and dopamine production decreases by more than 80%, the symptoms of Parkinson’s disease will appear. 2, environmental factors: abroad as early as the 1940s people have been concerned about environmental exposure factors, especially pesticides, metals and industrial solvents. early 80s found that smoking drugs mixed with neurophilic toxicants, namely 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is the causative factor of Parkinson’s disease. However, scientists soon found that there is no natural MPTP in nature, so many scientists devoted themselves to finding natural MPTP-like neurotoxicants or other environmental toxicants that may cause Parkinson’s disease, among which paraquat, rotenone, and insecticide of Dieldrin (dieldrin) have been studied intensively. However, as of now, there is no environmental substance that has been recognized as an environmental toxicant that causes Parkinson’s disease. 3, genetic factors: Although the occurrence of Parkinson’s disease is related to aging and environmental toxins, not all elderly people or people exposed to the same environment, even those who also inhale large amounts of MPTP, will develop Parkinson’s disease. Studies have found an aggregation of Parkinson’s disease in some families, with about 10% of Parkinson’s patients having a family history of the disease. This is despite the fact that mutations in this gene have been found to be the cause of only a very small number of patients with hereditary Parkinson’s disease. However, the fact that this area is rapidly becoming a hot spot for Parkinson’s disease research, this in-depth research, has greatly deepened the understanding of the occurrence of Parkinson’s disease and will certainly help people to seek new means of treatment for Parkinson’s disease, which is equally important for most patients with non-hereditary Parkinson’s disease. 4, possible related factors: According to epidemiological studies conducted in Beijing, Shanghai and Xi’an, the prevalence of Parkinson’s disease is higher in brain workers than in non-brain workers. Therefore, it is speculated that the onset of Parkinson’s disease may be related to long-term mental stress, low physical activity and high-fat diet. In conclusion, no single factor can completely explain the etiology of PD. Most researchers prefer that the etiology of Parkinson’s disease is the result of a combination of the above factors. For the majority of patients with Parkinson’s disease, it is more likely to be the result of a combination of genetic and environmental factors. In other words, genetic factors make him/her susceptible to the disease, and if he/she is later exposed to some environmental triggers that can lead to Parkinson’s disease, which worsen with age, the dopaminergic neurons progressively keep dying and degenerating, and eventually the clinical symptoms of Parkinson’s disease appear out of compensations.