Ulcers over the urethra in menopausal women usually require medication depending on the cause. Ulcers on the urethra are most often caused by bacterial infections, or syphilis. Commonly used drugs are penicillin, benzylpenicillin and so on. 1. Bacterial infection: If the bacterial infection, resulting in urethral ulcers, usually accompanied by urinary pain, urinary urgency, urinary incontinence, urination with burning sensation. Need to give timely anti-infection treatment, the ulcer surface can be used externally mupirocin ointment or erythromycin ointment, coupled with oral antibiotic drugs, such as cephalosporin preparations, penicillin, etc.. 2. Syphilis: If you are considering syphilis infection, you need to carry out syphilis serological examination, clear diagnosis, follow the doctor’s instructions to choose the treatment program, commonly used drugs are benzylpenicillin. Urethral ulcers may also be caused by other reasons, it is recommended to go to the regular hospital urology or dermatologic venereal disease, after a clear diagnosis of active treatment. The above drugs should be used under the guidance of a doctor.