High urine protein is the detection of protein in the body’s urine, most commonly when kidney disease occurs. Since protein is a valuable source of energy for the body, it should not be present in the urine under normal circumstances, and when a lesion occurs protein leaks out of the kidneys and its absorption by the glomerulus and tubules decreases causing urine protein. Urine protein can also occur in some physiological conditions, mostly due to heavy exercise and excessive protein intake at one time, which can lead to a physiological increase in urine protein. Most cases are due to pathological causes of increased urine protein, commonly seen in glomerulonephritis, renal tubular acidosis, azotemia, whether glomerulonephritis, hypertension-induced nephropathy, or diabetes-induced nephropathy, all make the renal tubular reabsorption of protein decreased, and the cell membrane permeability to protein increased, resulting in increased protein in the urine, and prone to hypoproteinemia. When urine protein is increased, it must be properly diagnosed and treated to avoid some other serious consequences.