Progesterone is a natural progesterone secreted by the ovarian corpus luteum. In vivo, progesterone has a significant morphological effect on the estrogen-primed endometrium and is required for the maintenance of pregnancy. Progesterone is still routinely administered intramuscularly in high doses for progesterone support in most IVF centers. Long-term intramuscular injections of this drug often cause adverse effects such as redness, swelling, pain, and extravasation of the drug. How to mitigate the adverse effects is a major concern for all patients. Progesterone injection is prone to injection site hard nodules, can be local hot towel wet compress 12 hours after injection Allergic reactions such as skin itching should be seen immediately, according to the condition of the appropriate change of medication. Hot compress Hot compress should be applied 2-3 hours after intramuscular injection, 15-30 minutes each time with hot towel wet compress, do not use hot water bag, electric heater instead, because the wet heat effect is more significant than the dry heat effect. Do not apply hot compresses immediately after injection. If you apply hot compresses immediately after injection, harmful microorganisms will easily invade from the needle eye, causing inflammatory reactions such as redness, swelling, itching and pain. For patients who do not plan to transfer embryos during the cycle, you can also use warm water diluted with magnesium sulfate powder as a wet compress for better results. Potato slices are applied with fresh potatoes washed and cut into 2-3mm slices to cover with intramuscular injections. External application of potato slices helps to relieve local hard nodules caused by intramuscular progesterone injection and has the function of anti-inflammation, pain relief, blood circulation and swelling.