It is good to change the medicine about once in 2~3 days after breast fibroid surgery, but the size and degree of the wound of each patient is different, etc., so it cannot be generalized and should be flexible to change the medicine. Breast fibroid surgery can be divided into minimally invasive surgery and traditional surgery. Traditional surgery requires an incision in the marginal part of the nipple under local anesthesia, after which the breast fibroid tumor is excised and then sutured for treatment. Minimally invasive surgery is accessed through small incisions and the tumor is removed sequentially. If minimally invasive surgery is used, the wound is relatively small and can be changed once every 2 to 3 days. If the treatment is through traditional surgery, the medication can be changed once every 2 days. In addition, when changing the medication, the wound should be observed for infection. If infection occurs, the frequency of medication change can be increased and local debridement can be carried out at the same time to avoid aggravation of infection. As each patient’s situation is different, it is recommended to follow the doctor’s instructions to change the medicine after surgery.