The most important treatment for pleomorphic adenoma of salivary glands is surgery, in addition to chemotherapy and radiation therapy. 1. Surgery: It is the first choice of treatment, aiming at removing the tumor. For superficial pleomorphic adenoma of parotid gland, the mass and part of parotid gland can be removed, while for deep pleomorphic adenoma of parotid gland, total excision of mass and parotid gland is needed. 2. Chemotherapy: benign pleomorphic adenoma of the parotid gland does not need to receive chemotherapy after radical resection, but for malignant pleomorphic adenoma of the parotid gland, chemotherapy is needed to inhibit the growth of the tumor, especially for distant metastatic pleomorphic adenoma of the parotid gland. Commonly used chemotherapy drugs include cisplatin and paclitaxel. 3. Radiation therapy: malignant pleomorphic adenoma of salivary glands can reduce the local recurrence rate by receiving radiation therapy after surgery. If the diagnosis of pleomorphic adenoma of salivary glands is confirmed, it is recommended to consult the doctor in time and standardize the treatment under the doctor’s guidance.