Clopidogrel is a drug that inhibits platelet aggregation and has a relatively small effect on the stomach compared to aspirin and other drugs. However, it can also affect the stomach in the presence of gastritis, gastric ulcers, and other diseases. Clopidogrel is different from aspirin in that it inhibits platelet aggregation by inhibiting ADP and activating platelets to achieve the purpose of anticoagulation and prevention of thrombosis. Generally speaking, clopidogrel rarely affects people who do not have primary pathology of the stomach. However, if the patient himself has gastritis, gastric ulcer and other diseases, the use of clopidogrel may lead to the aggravation of the condition, resulting in complications such as gastrointestinal bleeding. Therefore, people who need to take clopidogrel for long-term treatment usually add gastric mucosa protection drugs. The adverse reactions of clopidogrel also include abdominal pain, loss of appetite, skin rash, neutropenia, etc. It is prohibited for people who are allergic to clopidogrel, patients with peptic ulcer ulcer disease, and patients with intracranial hemorrhage. Therefore, for people who need long-term medication, they should strictly follow the doctor’s instructions and use the drug under the guidance of the doctor.