Taking transfer factor for two years will not hurt your kidneys, but it can lead to immune dysregulation and imbalance, and an overdose can also affect your stomach and intestines. Transfer factor is an immunomodulatory drug, a polynucleotide and peptide small molecule substance extracted from healthy human leukocytes. It can enhance and inhibit cellular immunity, and can correct immune dysfunction of the body. Because the drug has no toxic side effects and no drug residue, it will not cause damage to the kidney. However, long-term use will cause immunosuppression and immune dysfunction, secondary immune dysregulation, secondary immune imbalance, so although transfer factor can regulate the immune function, it should not be taken for a long time. In addition, the drug belongs to a kind of acidic drugs, a large amount of consumption will cause some stimulation to the gastrointestinal tract, which will lead to the emergence of gastric mucosal erosion, atrophy and other conditions, which will lead to heartburn, acid reflux and other symptoms, and burden on the gastrointestinal tract. It is recommended that patients use the drug under the guidance of a professional doctor, and seek medical advice promptly if any discomfort occurs. In addition to allergic to the drug, pregnant women, lactating women and other people are prohibited, do not take the drug on their own.