Endogenous osteochondroma is not necessarily a serious disease; if the disease is mild and the treatment is timely, it is usually not serious; if the disease is serious and there is the possibility of malignant changes, it is more serious. To determine whether the disease of endogenous osteochondroma is powerful or not, it needs to be based on the actual situation and cannot be generalized. Usually, endogenous osteochondroma is a benign cartilage tumor that occurs in the bone. If it is a solitary endogenous osteochondroma, the condition is mild, without malignant tendency, and the treatment is timely, usually endogenous osteochondroma is not serious. However, for multiple endogenous osteochondroma, there is a tendency of malignant change, the condition is serious and untreated, relatively speaking, it is more serious. With standardized treatment in the early stage, the prognosis of endogenous osteochondroma is generally good, which can control the further development of the disease, improve the clinical symptoms, and enhance the quality of life. To summarize, once diagnosed with endogenous osteochondroma, patients need to actively treat the disease, strengthen daily life management, follow the doctor’s instructions for regular follow-up, and monitor the changes of the disease.