If a patient sleeps until midnight with heart pain, the following factors should be considered: first, consider cardiogenic diseases, such as coronary artery disease unstable angina, acute myocarditis or acute pericarditis, infective endocarditis, arrhythmia, heart failure, will appear in the middle of the night due to increased vagal tone, resulting in pain in the precordial region, accompanied by clinical symptoms and manifestations of coronary artery ischemia, stenosis, spasm. Second, for respiratory diseases, especially in various factors leading to pneumothorax, pleural effusion, pleurisy, massive pneumonia, lung infection, there will also be patients who sleep until midnight with pain in the precordial region, but usually accompanied by dyspnea, the patient’s precordial pain will gradually increase with breathing. Third, if the patient has previous clear digestive system diseases, often in patients with gastroduodenal ulcers, there are clinical manifestations of acid reflux, heartburn and precordial pain in the middle of the night.