Children’s itchy buttocks at night are considered to be related to eczema, urticaria, infection, intestinal parasitism and so on. It is recommended to pay attention to the care of the affected area, give glucocorticoid, antihistamine, anti-infection, anti-parasite drug treatment. 1. Eczema: anal eczema is a common clinical skin disease of the anus, the specific cause of the disease is not yet completely clear, and is considered to be related to a variety of internal and external factors caused by delayed-type metamorphosis. Vitamin C, vitamin B, zinc oxide ointment, hydrocortisone ointment can be given to smear, if necessary, with loratadine syrup, can relieve itching. 2. Urticaria: Hives on buttocks, consider with the underwear is not breathable, long-term a posture, local extrusion, friction and other physical stimuli related. Commonly used clinical drugs include methylprednisolone, hydrocortisone, etc., which can relieve laryngeal edema. Loratadine and cetirizine can help relieve symptoms and improve quality of life. 3. Infection: Not paying attention to local hygiene, clothing too tight, not ventilated and breathable, can easily induce various infections, resulting in local itching and pain. For bacterial infection, erythromycin and fusidic acid ointment can be given. Fungal infections, can be given miconazole nitrate, ketoconazole ointment and other treatments. 4. Intestinal parasitic disease: intestinal pinworm infection, night parasites crawl out of the anus to lay eggs, causing itching. Albendazole tablets can be given to expel intestinal parasites. Children with symptoms of itchy buttocks, it is recommended not to scratch and stimulate, to avoid inducing infection. If necessary, go to the hospital dermatology department to see a doctor, clarify the cause, and treat as soon as possible.