Patients with a confirmed diagnosis of chronic hepatitis C are diagnosed with refractory hepatitis C if any of the following conditions are met (i) blood viral load (HCVRNA) greater than 106copies/ml; (ii) HCV viral genotype 1; (iii) no response to previous antiviral therapy; (iv) no durable response to previous antiviral therapy; (v) co-infection with other viruses, obesity, diabetes or insulin resistance; (vi) intolerance to interferon or ribavirin therapy. How to treat refractory hepatitis C: Interferon plus ribavirin is the best combination for hepatitis C treatment and the basic regimen for refractory hepatitis C treatment. Because it is refractory, it requires that patients fully understand the characteristics of the disease they suffer from before treatment, and that they are both fully prepared mentally to overcome the difficulties and work closely with their doctors with a strong determination to treat them. In recent years, our department has admitted more than a thousand cases of chronic hepatitis C patients, including many refractory hepatitis C. I remember a patient with cirrhosis C, who came to me many years ago, when he was still chronic hepatitis C. He was advised to undergo antiviral therapy, but the patient was busy at work, concerned about the many side effects of interferon and did not take the doctor’s advice. As with many patients with chronic hepatitis C who usually do not have many symptoms, this patient was so immersed in his career for many years that he neglected regular checkups, let alone timely treatment. By the time he was seen again, he had developed a dull complexion, a markedly enlarged spleen, and declining white blood cells and platelets, and was diagnosed with compensated cirrhosis. The patient regretted not applying the antiviral treatment regimen at the time, and despite being told that his liver reserve capacity was reduced, his blood picture was depressed, and he could not necessarily tolerate the side effects of interferon and ribavirin, the patient was adamant about antiviral treatment. According to the patient’s specific situation, the physician team developed an individualized antiviral treatment plan for him. After 15 months of treatment, the patient not only had no continuous monitoring of the virus, but also many indicators such as liver function, white blood cells and platelets were significantly better than before treatment, and his quality of life improved significantly… Many patients and their families are still very unfamiliar with the concept of hepatitis C. They went to a specialist hospital for examination After being told that the genotype belongs to the category of refractory hepatitis C, they are full of doubts and fears. After the doctor’s patient explanation and careful treatment, they are clinically cured, and the family’s happiness, joy and emotion are overwhelming. As doctors, we often worry about our patients first, but we also have too many opportunities to be happy with them! I would like to say that having hepatitis C is not terrible, even if it is refractory hepatitis C, do not lose confidence, as long as there is determination, confidence and perseverance, most patients can still achieve satisfactory results.