The side effects of targeted drugs are as follows: 1. rash, which can cause a widespread rash on the face or even the whole body. 2. cause hypertension and proteinuria, such as bevacizumab, erlotinib or anlotinib can cause hypertension at all levels, even grade 3 hypertension, as well as proteinuria. 3. cause liver function damage, such as erlotinib can cause elevated liver transaminases, etc. 4. others include viral activation, which is also a side effect of some side effects of targeted drugs. For example, nitrozumab is an immunosuppressive target drug, the use of targeted drugs to suppress immunity can lead to viral activation, such as the original hepatitis B virus carriers, can be in the immune system when the decline in viraemia.