Testosterone is as important to women as estrogen is to women, and it can play a pivotal role for men, determining whether you are “manly” or manly, as well as being a man’s most important fertility. Testosterone is mainly synthesized and secreted by the interstitial cells of the testes, with a daily production of 5-10mg. It has an important impact on health, including enhancing libido, strength, immune function, fighting osteoporosis and other effects. Loss of concentration, irritability and enjoyment of life, muscle or bone and joint pain, etc. If the above symptoms occur in men after middle and old age, they should be highly alert to whether it is late onset hypotestosterone (LOH). If the serum testosterone level is measured to be low, and then testosterone supplementation therapy is given after a good response, it can be diagnosed as late onset hypotestosterone (LOH), and no contraindication can be taken for a long time. If the effect of supplementation therapy is ineffective, further examination of other possible causes of symptoms is required. From the 1940s until now, late-onset hypotestis was first named men’s menopause syndrome, andropause, male menopause, and partial androgen deficiency syndrome in middle-aged and elderly men, until 2002 when the name late-onset hypotestis was recognized by the International Society of Gynecology and the European Urological Society and defined as an age-related The name Late onset hypospadias was recognized by the International Society of Gynecology and the European Urological Association until 2002 and defined as an age-related hypospadias that occurs in middle-aged and older men. The prevalence of hypogonadism in men aged 40-70 years is 30-40%, as China’s aging population has exceeded 10% of the total population and has entered an aging society. The health and quality of life issues of the aging population, especially the aging men, have attracted social and medical attention, and delayed hypogonadism seriously affects the quality of life of middle-aged and elderly men and brings adverse effects on multi-system and organ functions. In addition to ageing, testosterone deficiency is closely related to exposure to occupational and environmental toxins (desiccants, etc.), systemic chronic diseases, use of medications such as barbiturates and hypothalamic-pituitary-gonadal axis defects. Testosterone preparations are prescription drugs and must be taken under medical supervision. Early athletes took it as a stimulant because it makes muscles strong and stimulates red blood cell production, so the state does not allow it to be sold in pharmacies, and there are also contraindications when taking it, such as patients with prostate cancer, prostate enlargement with urinary difficulties or sleep apnea syndrome, etc. should be avoided.