Azithromycin and penicillin are able to be used together, but only if directed by a medical professional. Azithromycin is a macrolide antibiotic drug that can be used to treat infectious lesions caused by sensitive pathogens and is effective against a wide range of pathogenic bacteria. Penicillin is also an antibiotic drug with broad-spectrum antibacterial effects. Azithromycin and penicillin have different antimicrobial spectrums, and when applied together it may be because of the need to treat different pathogens as a way to achieve good efficacy. Common adverse reactions associated with azithromycin are gastrointestinal. The common adverse drug reaction associated with the use of penicillin is an allergic reaction. Whether azithromycin or penicillin is used, it must be contraindicated in the first place in those who are allergic to the ingredients contained in the drug. It should be noted that azithromycin should be used with caution in people with impaired liver function, and if hepatitis occurs after the use of the drug, it is necessary to stop using the drug. Before using penicillin, a penicillin skin test must be done. Although it is said that azithromycin and penicillin can be used in combination, individuals are not allowed to use them indiscriminately, and they must be evaluated by a medical professional before they can use the drug.