Pustules on the soles of the feet may be caused by palmoplantar pustulosis, local bacterial infections and other diseases. 1. palmoplantar pustulosis: a chronic inflammatory autoimmune disease, mainly manifested as aseptic small pustules on the skin of palmoplantar area, but also manifested as erythema, desquamation, thickening of plantar skin, dryness, itching sensation, burning sensation, and nail changes and other symptoms, which can be manifested as pustules on the soles of the feet. 2. Local bacterial infection: related to long time walking, strenuous exercise or shoes are too small, mainly manifested as local skin redness, swelling, pain, severe cases can be accompanied by pustule formation, rupture can be discharged pus, pus and blood, which can also be manifested as pustules on the soles of the feet. There are many other causes of pustules on the soles of the feet, which should be emphasized, and timely consultation should be made to identify the cause of the disease, and further treatment or therapy in accordance with medical advice.