There is no “Budesonide and Tretinoin which effect is good”, Tretinoin and Budesonide two mechanism of action and indications are different, according to the actual condition to choose the appropriate medication, can not compare which effect is good. Tretinoin is usually made into sprays and creams, is a strong glucocorticoid. It has obvious anti-allergic effects and is suitable for atopic dermatitis, neurodermatitis, pruritus, seborrheic dermatitis and so on. Long-term use may have local capillary dilation, skin atrophy, hyperpigmentation and other adverse reactions. It should not be used on broken skin, and is contraindicated for those who are allergic to tretinoin. Budesonide is usually made into an aerosol and is indicated for bronchial asthma with symptoms of wheezing, shortness of breath, coughing and chest discomfort, and patients tend to have attacks at night or early in the morning. Budesonide is a potent glucocorticoid that is effective in localized anti-inflammatory therapy. Adverse reactions to budesonide aerosol include throat discomfort and oral infections. It is contraindicated for those who are allergic to budesonide. To summarize, the mechanism of action and indications of both trimethoprim and budesonide are different, and it is necessary to decide which drug to use according to the condition, and it is recommended to follow the doctor’s instructions to use the drug, and do not use the drug on your own, so as not to cause adverse effects.