The etiology of SLE is still unclear. It is currently believed that the development of SLE is the result of a combination of factors, both inherited, sex hormones and other intrinsic factors, and also related to environmental factors, infections, drugs and other factors. The interaction of genetic factors, environmental factors, endocrine and autoimmune factors leads to the dysfunction of the immune system of the body, producing a large number of autoantibodies, causing acute and chronic inflammation and tissue necrosis, or cell destruction, which leads to multi-system damage of the body. SLE is a systemic disease with any kind of skin rash, muscle, bone and joint pains, as well as heart, lung, liver, spleen, kidney, brain, eye, ear, teeth and hair lesions. SLE is a typical heterogeneous disease with a wide range of manifestations and different manifestations in different stages of the disease. Although the American Rheumatism Association’s SLE diagnostic criteria, which are commonly used now, have good sensitivity and specificity, including clinical manifestations and laboratory tests such as autoantibodies, and those who meet four or more criteria can be diagnosed as SLE, some patients’ clinical and laboratory tests meet the diagnostic criteria but are not SLE, which sometimes leads to misdiagnosis. Therefore, early diagnosis is very important to control the progression of the disease and improve the prognosis of patients. In order to confirm the diagnosis at an early stage, for unexplained fever, malaise, hair loss, general malaise, weight loss, facial erythema, erythema of the fingertips, whitening or turning purple when the hands and feet are cold, recurrent oral ulcers, photosensitivity, arthralgias, superficial lymph node enlargement, menstrual bleeding, purpura, hematuria, proteinuria, pleurisy, anemia, decreased white blood cell and platelet count, recurrent miscarriage, headache, hallucinations, hallucinations, persistent diarrhea, vomiting The diagnosis of SLE is more complicated, so it is necessary to go to a regular hospital and a rheumatologist for consultation and treatment, and not to diagnose by oneself to avoid misdiagnosis. Why are you afraid to take hormones For the treatment of SLE with a clear diagnosis, hormones are the most effective drugs. It is because of the use of hormones that doctors have been able to save countless lives from the death line, and it is currently recognized as the most “powerful” weapon for the treatment of SLE in the world. If necessary, the combination of appropriate immunosuppressive drugs can help reduce the dose of hormones and induce and maintain remission. There are many of these drugs, such as cyclophosphamide, methotrexate, leflunomide, and leucovorin, all of which need to be applied under medical monitoring. In recent years, with the rapid development of science, some new drugs and treatments have been introduced, such as stem cell therapy, plasma replacement, biological agents, etc., which bring new hope for the treatment of SLE. However, there is still no clinical alternative to hormones because the long-term efficacy needs to be proven. Hormone is a double-edged sword, it has some well-known side effects while treating the disease, so the treatment should also pay close attention to the presence of infection, hypertension, diabetes, peptic ulcer, osteoporosis, aseptic osteonecrosis and other adverse reactions. Therefore, patients must strictly follow the specialist’s instructions and must not increase or decrease the dose or stop the medication without authorization. Reasonable and correct use of hormones can not only quickly control the disease and bring about long-term remission, but also keep the side effects of hormones to a minimum. Never believe in any drug therapy that can replace or stop the use of hormones. In reality, in the past, due to insufficient understanding of the effects and side effects of hormones, people once had fear and resistance to hormones due to side effects such as aseptic osteonecrosis caused by hormone abuse, thus losing the time to treat SLE. Some friends are also concerned about which foods can be eaten and which cannot be eaten?SLE patients generally have no special contraindications to diet, but some foods, such as celery, figs, mushrooms, smoked food, alfalfa, bean pods, toon, parsley and other foods have induced photosensitivity or stimulate immune effects, should be avoided as much as possible. You can eat more bananas, apples, oranges, tomatoes and other fruits and vegetables rich in potassium, but if the patient has renal failure, high blood potassium can not eat the above foods. Patients with diabetes also need to limit staple foods and sweets, and patients with hypertension should eat a light, low-salt diet. patients with SLE should also be aware that some drugs have lupus-inducing effects, such as hydrazidiazine, procainamide, isoniazid, chlorpromazine, methyldopa, etc., and should be avoided. The treatment principles of SLE are: active treatment during the active period to make it go into remission; adjustment of medication during the remission period to minimize drug side effects and prevent disease recurrence. Preferably, patients should pay attention to do five to five don’t: to follow medical advice, to take sufficient rest, to be mentally happy, to eat reasonably, to review regularly; don’t use drugs indiscriminately, don’t overwork, don’t sun exposure, don’t hearsay, don’t stop drugs suddenly. Medical researchers are working hard to find the cause of its development, and we believe that in the near future, SLE will have the day of complete cure!