The main dangers of palmoplantar keratosis are the impact on the quality of life and inheritance to the next generation. Palmoplantar keratosis is a skin disease, the disease is related to epidermal cell proliferation, keratin shedding abnormalities and genetic factors, some patients can be due to psoriasis, lichen planus and other complications of palmoplantar keratosis. Some patients with palmoplantar keratosis have atypical symptoms, while others have symptoms such as excessive sweating, cracking of the skin, itching, and difficulty in moving around, which is why it affects the quality of life. Because palmoplantar keratosis is genetically linked and occurs in people with a family history of palmoplantar keratosis, it can be passed on to the next generation. Keratosis palmoplantaris is usually not self-healing, but if the patient actively cooperates with the doctor’s treatment, the symptoms of the skin lesions can be improved, and the harm to the quality of life can be reduced. It is recommended that people with palmoplantar keratosis actively cooperate with the doctor’s treatment, and not to use drugs or prescriptions on their own. Pay attention to daily skin care, avoid foreign body friction stimulation or contact with harmful chemical substances.