There are different causes of nighttime cough, different treatment methods, and individual variability, so there is no such thing as the most effective way. Common causes include respiratory system diseases, circulatory system diseases, digestive system diseases, etc. The treatment should be targeted according to different causes. 1. Respiratory system diseases: such as cough variant asthma, mainly due to contact with irritating gases, allergic substances and other triggered cough, mainly dry cough, night or early morning aggravation, treatment can be taken montelukast, budesonide formoterol powder inhalation to improve the cough symptoms. 2. Circulatory system diseases: such as heart failure, mainly due to pulmonary edema caused by pulmonary stasis, cough discomfort, the treatment is mainly to take furosemide, nitroglycerin, digoxin and other diuretic, vasodilator, cardiac and other therapies, cardiac function can be relieved after the improvement of coughing symptoms. 3. Digestive system diseases: such as gastroesophageal reflux disease (GERD), mainly due to the dysfunction of the lower esophageal sphincter, resulting in gastric reflux to the throat or trachea, causing cough. Treatment can take acid suppressants such as omeprazole and gastric power drugs such as mosapride to improve cough symptoms. There are many other causes of nocturnal cough, such as postnasal drip syndrome and environmental irritation. It is recommended that if the cough symptoms recur without relief or aggravation, timely consult a doctor, improve the examination, and follow the doctor’s instructions for medication, so as not to delay the condition.