Antinuclear antibody is negative and anti-RO52 antibody is positive. Firstly, it is recommended to review the test except for test errors, and secondly, to clarify the presence of rheumatic immune diseases with the patient’s clinical manifestations.
Antinuclear antibodies are a group of autoantibodies against DNA, RNA, proteins or molecular complexes of these substances in the cell nucleus. Anti-RO52 antibody is a common antibody in the antibody spectrum. Positive anti-RO52 antibody can be seen in autoimmune diseases such as dry syndrome and systemic lupus erythematosus. It is also seen in a small number of normal individuals or in cases of chronic infections.
It is rare to see patients who are negative for anti-nuclear antibodies and positive for anti-Ro-52 antibodies. In this case, firstly, it is recommended to review the test or change to another test method to confirm the correctness of the results.
Secondly, it should be combined with other clinical manifestations such as dry mouth, dry eyes, swollen joints, enlarged parotid glands, etc. to determine whether the patient is suffering from autoimmune diseases, especially dry syndrome.
It is recommended that the patient should seek medical advice in time to further clarify the diagnosis under the guidance of the doctor and follow the doctor’s instructions to standardize the treatment.