The normal thickness of the spleen is 30-40 millimeters. If 53 millimeters may be splenic cysts, cirrhosis and other diseases caused by the increased thickness of the spleen. 1. Splenic cyst: it is a verrucous cystic lesion of splenic tissue, and the main causes are parasitic infection, congenital development or tissue misplacement, splenic trauma, inflammation, childbirth and splenic infarction, and increased thickness of the spleen, etc. Clinical manifestations include discomfort in the upper left abdominal area, dyspepsia, constipation, coughing, and respiratory difficulties. 2. Cirrhosis: it is a disease in which all kinds of chronic liver diseases have been developing and eventually characterized by chronic inflammation and diffuse fibrosis of the liver, and cirrhosis can also lead to increased thickness of the spleen. Increased spleen thickness may also be seen in hematologic diseases, splenic abscess, splenic hemangioma, splenic lymphoma and other diseases. If the symptoms of increased spleen thickness appear and continue to be unrelieved, it is necessary to consult a doctor in time for treatment, and it is important not to be negligent so as not to delay the condition.