Most patients with blisters after frostbite have second-degree frostbite. The first thing that should be done is to get out of the cold environment and rewarm quickly. If clothes and limbs are frozen together, they should not be removed reluctantly, but should be cut open after they have melted in warm water. For patients with second-degree blisters after frostbite rewarming, the wound surface is dry and clean, and can be wrapped with soft dry gauze to avoid rubbing the skin and prevent compression. Larger blisters should be disinfected under aseptic conditions, such as with iodophor, and the blister fluid within them should be aspirated with a sterile empty needle and then continued to be dressed with sterile gauze. In case of infection, wet dressing with gauze of antibacterial medication should also be applied, and in case of frostbite cream using wrapping or semi-exposure therapy, if pain is obvious, local closure therapy can also be applied to reduce vascular spasm and progressive aggravation. In addition, the application of low-molecular dextrose can be used for anticoagulation, and local nutrition should be strengthened by giving high-calorie, high-protein and high-vitamin foods.