Pityriasis rosea is not a precursor to syphilis. The cause of pityriasis rosea is unknown, may be related to infection, allergy, drugs, immune dysfunction, etc., covered with furfuraceous scales of rose-colored macules, maculopapular rash, lesions of the long axis is more parallel to the skin lines and other symptoms, often occurs in the torso and proximal limbs, but also may be in the neck, face and other parts of the body, the regular treatment, the prognosis of the majority of patients is good. Syphilis is a sexually transmitted disease caused by syphilis spirochete infection, which can be transmitted through sexual transmission, mother-to-child transmission and blood transmission. After regular treatment, the prognosis of early syphilis is good, and the prognosis of late syphilis is often poor. It is recommended that patients according to their own situation, such as abnormal skin lesions on the body, timely to the regular hospital dermatology consultation, follow the doctor’s instructions to clarify the diagnosis, timely treatment.