Fewer antimitochondrial antibodies m2 become positive and then turn negative, and most patients are positive for life. Antimitochondrial antibody M2 positivity may lead to cirrhosis. Antimitochondrial antibody M2 is sensitive to primary biliary cirrhosis. Upon specific testing, patients with primary biliary cirrhosis can be positive for antimitochondrial antibody M2 in more than 90% of cases. It is often used as an important laboratory diagnostic index for primary biliary cirrhosis. Anti-mitochondrial antibody m2 positive patients must actively cooperate with doctors to carry out regular treatment, in the life and diet should also pay attention to the appropriate regulation: should be absolutely prohibited to quit smoking, regular life, do not stay up all night, more rest, try not to engage in heavy physical labor, and participate in appropriate sports activities. The patient’s diet should be light, easy to digest, eat more fish, shrimp, beef, soy products, eggs, dairy products and other high-quality protein-rich food, eat more fresh vegetables and fruits, avoid spicy, stimulating food, and do not consume too greasy food.