In clinical practice, if severe osteoarthritis of the knee occurs, artificial joint replacement is usually used in treatment. The exact cost should vary depending on the material and origin of the joint. If a domestic artificial knee replacement is used, the approximate cost is around 30,000-35,000 dollars for a 2-week hospitalization with no abnormalities occurring during the hospitalization. If imported artificial knee replacement is used, the hospitalization time is also 2 weeks, and the approximate cost is about 40,000-50,000 yuan. However, the specific cost should be based on the local price standard, because the hospital level is different, the region is different, the specific cost may also be slightly different, should be based on the local fee standard.