A skin test is required to administer penicillin. Penicillin is indicated for various infections caused by sensitive bacteria, such as abscess, bacteremia, pneumonia and endocarditis. In clinical application, patients may have adverse reactions such as rash, urticaria, fever, asthma, anaphylaxis, etc., of which anaphylaxis is the most serious and may even lead to death. Penicillin as a semi-antigenic agent can be combined with some of the body’s internal certain proteins to induce a type I allergic reaction, which can lead to a large number of histamine, bradykinin and other sensitizing substances in the patient’s bloodstream, which can lead to hives, angioedema, itching and other diseases, and it is very easy to induce anaphylactic shock and lead to death if used in a large dosage. Skin test is an abbreviation of skin sensitization test, which is a specific clinical examination to avoid more serious adverse reactions caused by blind use of drugs. Therefore, when using penicillin for the first time, it is necessary to undergo a strict skin sensitivity test to avoid unnecessary health effects after the drug enters the human body.