Glucose-lowering drugs suitable for patients with emaciation are mainly insulin secretagogues, common drugs include glimepiride, gliclazide, glipizide, repaglinide and so on, this kind of drug generally does not have the effect of weight loss; in addition, insulin is also suitable for patients with diabetes mellitus with emaciation, the specific use of drugs should be in accordance with the doctor’s instructions. There are many kinds of hypoglycemic drugs for the treatment of diabetes mellitus, and it is necessary to choose the appropriate drug for the treatment according to the patient’s body type and blood glucose control situation. The main hypoglycemic drugs suitable for patients with wasting type are insulin promoters, and the common drugs are glimepiride, gliclazide, glipizide, reglanatide, etc. In addition, insulin is also suitable for patients with diabetes. In addition, insulin is also suitable for diabetic patients with wasting type. Metformin and other drugs have a weight loss effect, and should be used with caution in patients with diabetes of the wasting type. Specific medication should be under the guidance of the doctor, not self-medication.