Febuxostat, a uric acid-lowering drug, should only be used two weeks after the acute arthritic phase of gout has ended and the disease has entered a stable phase. The use of febuxostat during the acute active phase of the disease can cause fluctuations in uric acid in the body and prolong the acute attack. When febuxostat is used for the first time, it should be used in combination with colchicine to prevent the recurrence of acute attacks of gouty arthritis. In addition, it is recommended to start with a small dose of 20 mg per day and gradually increase the dose according to the decrease of uric acid. For patients who have been taking febuxostat orally, if an acute attack of gouty arthritis occurs during the course of treatment, there is no need to discontinue febuxostat and it can be continued.