The chance of cancer in total colitis is not high. The chance of cancer in colitis is related to age, duration of the disease, extent of the lesion, activity of the lesion, family history, and histologic changes. 1. Age: young patients with colitis have a relatively higher chance of developing cancer than old patients. 2. Duration of the disease: those with a longer course of colitis are prone to cancer, especially those with a course of more than 10 years. 3. Extent of the lesion: patients with total colitis have a higher chance of cancer than those with limited colitis. 4. Activity of the lesion: if colitis continues to be in the flare-up stage, the chance of cancer is higher than that in the stable stage of colitis. 5. Family history: patients with colitis who have a family history of colorectal tumors have a higher chance of developing cancer. 6. Histologic changes: moderate or severe atypical hyperplasia or verrucous polyps are precancerous lesions and have a higher chance of becoming cancerous. Patients with total colitis are advised to cooperate with doctors for active treatment to avoid cancer.