Lamellar soft tissue shadow with multiple calcifications in the splenic region and splenic atrophy should be specifically identified to make a diagnosis and treatment, and the management includes conservative observation and surgical treatment. The flaky soft tissue shadow in the splenic region may be caused by hemangioma or cyst, etc., and the multiple calcified foci may be due to localized calcium salt deposition in the spleen, resulting in dystrophic calcification; there are various causes of splenic atrophy, such as malabsorption syndrome, hyperthyroidism, hematologic diseases, etc., and the specific causes need to be identified by relevant examinations. It is recommended to carry out further examination to clarify the cause of the disease and then carry out relevant treatment, such as benign lesions, follow-up observation, usually pay attention to appropriate exercise, pay attention to diet, etc., such as the spleen is no longer functional or malignant lesions, splenectomy should be carried out, and laparoscopic splenectomy is generally an option.