Knee pain should be treated with general therapy, medication, physical therapy and surgery according to the cause. Common causes include knee strain, knee arthritis, knee fracture and so on. 1. Knee joint strain: In knee joint strain, there is no obvious damage to the joint structure, so it can be relieved by rest, braking and physical therapy such as heat therapy, intermediate frequency electrotherapy, etc. When the pain symptoms are obvious, it can be treated by oral non-steroidal anti-inflammatory and pain relieving medication, such as acetaminophen and celecoxib. 2. Knee arthritis: For early osteoarthritis, rheumatoid arthritis or traumatic arthritis of the knee, oral non-steroidal anti-inflammatory drugs such as Celecoxib and anti-rheumatic drugs such as Leflunomide can be used to treat the pain symptoms, and the pain symptoms can be relieved; in the late stage, surgery can be carried out to treat the pain symptoms, such as osteotomy and orthopedic surgery, unicondylar replacement surgery, or total joint replacement surgery, and so on. 3. Knee fracture: For pain caused by knee fracture, the pain can be gradually improved after active treatment of the fracture. If there is no displacement of the knee joint fracture can be cast external fixation, the displacement of the fracture in the surgery of internal fixation will also gradually reduce the pain. There are many other causes of knee pain, such as bursitis, lumbar disc herniation, etc. If the pain persists, it is necessary to consult a doctor in a timely manner, complete the relevant examinations, clarify the cause of the disease, and follow the doctor’s instructions to carry out targeted treatment in order to avoid delaying the condition. The medication should be applied according to the doctor’s prescription.