Whether osteoarthritis can take levofloxacin hydrochloride depends on the patient’s condition, patients without infection generally do not use levofloxacin hydrochloride, patients with infection can use levofloxacin hydrochloride. Osteoarthritis is caused by degeneration and degeneration of articular cartilage, not due to bacterial infection, and levofloxacin hydrochloride is a kind of antibacterial drugs, osteoarthritis patients generally do not take levofloxacin hydrochloride treatment. However, when osteoarthritis is accompanied by bone and joint infections and urinary tract infections, levofloxacin hydrochloride can be used for treatment as prescribed by the doctor. Levofloxacin hydrochloride is contraindicated in patients with allergies, pregnancy, lactation, and children. Taking the drug may cause nausea, vomiting, dizziness, headache, hepatotoxicity, blood sugar disorders and other adverse reactions. Osteoarthritis patients should go to the hospital in time, avoid self-medication at home, should be under the guidance and advice of the doctor for regular treatment.