Betalac is a common drug used by people with high blood pressure. Some hypertensive patients are more enthusiastic, they use betalac with better effect, and immediately tell others, as a result, others take this drug, the heart rate is slow to more than 50 times, it is very difficult. In fact, Betalac is suitable for hypertensive patients with fast heart rate and combined coronary artery disease, but it should be prohibited for those with slow heart rate (<60 beats/min), asthma, severe cardiac insufficiency or with second degree type II or higher atrioventricular block! In addition, vertigo and fatigue may occur during treatment with Betalac and should therefore be used with caution by those driving and operating machinery. So what are the characteristics of Betalac and what are the main groups of people for whom it is indicated? The currently marketed Betalac is divided into two types of tablets: generic and extended-release tablets. The generic names are metoprolol tartrate and metoprolol succinate extended-release tablets, which belong to the class of beta-adrenergic receptor blockers (beta-blockers for short). They are both highly lipid-soluble selective β1 blockers. The highly lipid-soluble drugs are mainly metabolized in the liver, and a small amount is excreted in the urine as a prototype, while the biggest advantage of extended-release tablets is that the duration of action is longer than that of ordinary tablets, i.e., longer-acting and more convenient to take, generally only once a day. The main groups of people for whom betalactam is indicated are: young hypertensive patients without complications, perioperative hypertension, tachyarrhythmias (e.g. sinus tachycardia, atrial fibrillation), coronary artery disease (e.g. stable angina, post-myocardial infarction, variant angina, etc.), hypertrophic cardiomyopathy, aortic coarctation, high circulatory dynamics such as hyperthyroidism, increased sympathetic activity such as with anxiety and stress, etc. Cardiac neurosis with increased mental stress. In recent years, it has been used for the treatment of chronic heart failure. According to a survey conducted in 2004, beta blockers ranked 5th among the most commonly used antihypertensive drugs by doctors at all levels, and betalactam was the most commonly used beta blocker. It exerts its antihypertensive effect by antagonizing the excessive activation of sympathetic nervous system, including reducing cardiac output, inhibiting renin release and angiotensin II production, blocking the release of norepinephrine from sympathetic nerve endings, reducing central vasoconstrictor activity, and improving the blood pressure regulation function of pressure receptors. Precautions: 1. The dose should be individualized in the treatment of patients with different indications to avoid the occurrence of bradycardia. It is generally used for patients with heart rate greater than 70 beats/min. If symptomatic severe bradycardia (heart rate less than 50 beats/min) occurs after medication, the dose should be reduced or temporarily discontinued instead of stopping the drug, otherwise it is easy to cause a rebound increase in heart rate, which has the risk of causing frequent myocardial ischemia or angina symptoms. 2, should be taken on an empty stomach, taking the drug with a meal can increase its bioavailability by 40%. In addition, and other drugs have pharmacokinetic and pharmacodynamic interactions. For example, aluminum salts, cholestyramine (clofentezine), clofentezine can reduce its absorption; alcohol, phenytoin sodium, rifampin, phenobarbital and smoking can induce hepatic biotransformation enzymes, thus reducing the plasma concentration and half-life of betalactone; cimetidine and hydrazinepyridazine can increase the bioavailability of betalactone by reducing hepatic blood flow. Verapamil, diltiazem, and various antiarrhythmic drugs can inhibit sinus node function and atrioventricular conduction, which should be used with caution. Indomethacin and other non-steroidal anti-inflammatory drugs can antagonize the hypotensive effect of betalactam. 3.It may aggravate the symptoms of peripheral vascular circulation disorders such as intermittent claudication, and should be used with caution. 4.It may lead to increased airway resistance, and should be used with caution in patients with bronchial asthma or other chronic obstructive pulmonary disease, and adequate bronchodilator treatment should be given at the same time. 5.It has an effect on glucose metabolism and can partially mask the symptoms of hypoglycemia, so it should be used with caution. 6.Patients with pheochromocytoma who use betalactone should use alpha-blockers beforehand or in combination. 7.Can not be used in patients with pathological sinus node syndrome or slow fast syndrome and sinus arrest where syncope may occur. 8, Central nervous system adverse reactions include fatigue, headache, sleep disturbance, insomnia and excessive dreaming, as well as depression. Fatigue may be related to reduced blood flow to skeletal muscles and may also be related to central effects. Finally, it should be reminded that the characteristics of each hypertensive patient are not exactly the same, some have high systolic blood pressure, some have high diastolic blood pressure, some have fast heart rate, some have slow heart rate, some have diabetes, some have renal insufficiency, some have asthma, and some have gout ...... so their own experience should not be freely recommended to other patients, and others The experience of others should not be used. On the one hand, you may do a bad thing with good intentions, and on the other hand, you may run the risk of serious adverse reactions. Like the story mentioned earlier. The right way is to let your doctor fully understand your condition through consultation, physical examination and ancillary tests, and let your doctor help you choose your antihypertensive medication. After taking the medication, you can monitor your blood pressure and heart rate at home and give feedback to your doctor at the next follow-up visit, along with the changes in your symptoms after taking the medication, so that your doctor can adjust the medication and gradually help you to control your blood pressure within the target value, while minimizing the occurrence of adverse reactions.