Lactulose does not have dependence, lactulose is in the form of a syrup and is used in the clinic mainly to improve the symptoms of constipation, is used for chronic or habitual constipation, used to regulate the physiological regularity of the colon, as well as preventing, as well as treating, hepatic encephalopathy and comatose states. The starting dose is usually 10-30 ml per day, depending on the patient’s constipation, and is adjusted according to the patient’s response to the medicine and the condition of the stools. It does not produce dependence, and abdominal distension may occur in the first few days of taking it, which disappears with the continuation of the treatment. If overdose may appear abdominal pain and diarrhea, reduce the amount can be relieved, will not cause electrolyte disorders, will not cause dependence, and for pregnant women and children is also very safe. Although it is sweet, it is a highly permeable laxative, so it does not affect diabetic patients very much, and its widespread use in the clinic will not cause patient dependence.