The patient’s inability to open the upper eyelid may be caused by sleep deprivation, keratitis, myasthenia gravis and other reasons. 1. Lack of sleep: If patients often stay up too late and use their eyes excessively in the near future, resulting in too short a sleep, the eyes do not get enough rest, there will be sleepiness and the phenomenon of the upper eyelid can not be opened, which is a normal physiological phenomenon, and can be relieved after appropriate rest and does not require special treatment. 2. Keratitis: If the patient’s resistance declines recently, the cornea’s defense ability is weakened, and external or endogenous pathogenic factors invade the corneal tissue can lead to keratitis. Under the stimulation of inflammation, the patient’s eyes secrete a large amount of mucopurulent secretions, purulent secretions are easy to stick the eyelids, the patient will show the symptoms of the upper eyelid can not open up. 3. Myasthenia gravis: Myasthenia gravis is a kind of neuromuscular junction dysfunction disease, and patients can show weakness of eye muscles, medullary muscles, respiratory muscles and limb muscles. Due to the weakness of the eye muscle, it can lead to the patient’s upper eyelid muscle can not be contracted, then it will show that the upper eyelid can not be opened. It is recommended that patients with prolonged and unrelieved eye opening difficulties seek medical attention to evaluate their condition and follow medical advice.