Physiological or pathological causes can lead to sudden shaking of the body during sleep, and the pathological causes include epilepsy and hypocalcemic convulsions. 1. Physiological causes: As the body enters deep sleep, the muscles of the whole body relax, and its feedback effect on the brain cells is weakened, leading to the activation of the brain’s protective mechanism and the release of impulses to make the body’s muscle contraction, the symptoms of sudden shaking of the body during sleep can appear in the clinic. 2. Epilepsy: mainly caused by focal epilepsy. Epilepsy mostly occurs at night during sleep, and the symptom of involuntary shaking of limbs can appear, which is caused by abnormal discharge of brain cells. 3. Low-calcium convulsions: one of the important elements to maintain muscle excitability is calcium ions, and calcium deficiency can easily cause muscle spasms, leading to limb shaking. Therefore, it can lead to sudden body shaking while sleeping. Frequent sudden body shaking while sleeping may also be caused by other reasons. It is recommended that patients go to the Neurology Department of the regular hospital in time, and improve the relevant auxiliary examinations under the guidance of a professional physician to clarify the cause of the disease, so as to avoid delaying the condition.