If there is an abnormality of the ST segment in the ECG, the first thing to do is to distinguish this ST segment abnormality, whether it is meaningful or not. If there is no meaningful ST segment abnormality, also called non-specific ST segment changes, this situation does not require any treatment, and regular observation is sufficient. If the patient has uncomfortable symptoms, it can be combined with the examination of cardiac enzymes, cardiac ultrasound, and even a chest X-ray. If the patient’s ST segment abnormality belongs to horizontal shift of ST segment, or downward sloping shift of ST segment, or the ST segment is elevated upward, it is considered that the patient has acute myocardial ischemia, and it is recommended that the patient should be treated with antiplatelet, improve circulation and other symptomatic supportive therapy. At the same time, we need to further clarify the current condition, if the ST segment is elevated upward, it is considered that acute myocardial infarction may have occurred, and then it may need to be combined with coronary intervention.