The termination of persistent hiccups, known as eructation, includes treatment of the cause and treatment of the symptoms. Hiccups are mainly triggered by spasmodic contraction of the diaphragm. Some common causes of physiologic hiccups include eating too fast, overfilling, and eating foods that are too spicy, hot, or cold, which stimulate the neural reflex arc. Some central organic lesions, such as intracranial tumors and encephalitis, can also trigger organic hiccups. For the physiological ergonomics, most of them can be relieved on their own, and some of them cannot be relieved, symptomatic treatment can be carried out, including drinking water in large gulps, gently stimulating the pharynx, holding the breath after a deep inhalation, and so on, which can also divert the attention, inhibit the excitatory conduction of the vagus nerve, and block the reflex loop of the ergonomics, which has a certain therapeutic effect on the ergonomics. For organic eructation, it is necessary to actively treat the primary disease, such as surgery or radiotherapy treatment for intracranial tumors, and antiviral or anti-infection treatment for encephalitis. Meanwhile, for persistent hiccups, calcium antagonists (carbamazepine) and antiepileptic drugs (phenytoin sodium) can be used to inhibit spastic contraction of the diaphragm. In severe cases of hiccups, it is recommended to seek medical advice and treatment under the supervision of a doctor. Medications should be taken under the supervision of a physician.