For some complex congenital heart diseases, the mosaic treatment model combining medical interventional techniques with surgical procedures has become a major development, and the application of interventional techniques to support surgical procedures in the perioperative period can achieve better treatment results. Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, with an incidence of about 10% of all congenital heart diseases and 50% of cyanotic congenital heart diseases. Currently mosaic techniques (compound surgery, Hybird surgery) are playing an increasing advantage in the correction of severe tetralogy of Fallot. Severe TOF is treated with collateral vascular occlusion before radical surgery, using Plug vascular plug, (PDA) Amplatzer blocker, and COOK non-controllable spring coil to embolize the collateral vessels of the body lung. After the collateral vascular occlusion, a stage I radical surgical procedure was performed immediately. Satisfactory results were obtained for all procedures. Mosaic (hybrid) surgery for severe TOF is safe, effective, feasible, and more effective than a single surgical procedure.