Irregular periods can lead to non-pregnancy because if you have irregular periods you don’t ovulate regularly and conception is more difficult. Patients with polycystic ovary syndrome will have irregular periods and never have mature follicles to ovulate can lead to non-pregnancy. Patients with prolonged, shortened or irregular menstrual cycles and prolonged periods will have difficulty conceiving as long as they are monitored for the absence of a mature follicle. Therefore, it is important to regulate menstruation and especially monitor ovarian function, i.e., follicular maturation, so that as long as there is a normal discharge of mature follicles each month, there is a probability of pregnancy. If there is no mature follicle discharge at all times, it will lead to non-pregnancy.