There is no such thing as the most effective medicine for cracked hands. Cracked hands may be related to fungal infections, eczema, and vitamin deficiencies, and can be treated with medications such as bifonazole cream, halometasone cream, and vitamin ointment. 1. Fungal infection: If the cracked hand is caused by fungal infection, you can use topical antifungal drug bifonazole cream, after applying the drug, seal the area where the drug is applied, and then use mild, non-irritating moisturizers, while taking antifungal drugs orally, such as itraconazole. 2. Eczema: If the hand cracking is caused by eczema, don’t use alkaline detergent, don’t over wash, pay attention to skin moisturizing, adhesive tape is not allergic to can be used externally tretinoin cream, adhesive tape allergic to can be used halomethasone cream, and at the same time with the urea cream, preserving the skin moist. 3. lack of vitamins: hand cracking may also be caused by a lack of vitamins, you can use vitamin ointment for treatment, can be very effective in relieving the phenomenon of hand cracking, in the daily life, be sure to eat some fruits, vegetables containing vitamins food, so that it can be very good to prevent the occurrence of hand cracking. The use of the above drugs should follow the doctor’s instructions. It is recommended that patients go to the hospital in a timely manner, to clarify the cause of the disease, under the guidance of the doctor to choose the appropriate treatment.