Gastrointestinal adverse reactions to sartans may result in loose stools, but they need to be excluded as a result of gastrointestinal disorders. Sartan antihypertensive drug adverse reactions are mainly irritating dry cough and angioedema, but also nausea, vomiting, dizziness and other discomforts, but dilute stool, diarrhea symptoms are rare. Therefore, sartan antihypertensive drugs may lead to loose stools, but this situation is rare, such as the patient after taking medication, loose stools, it is recommended that patients first rule out gastrointestinal diseases. Sartan antihypertensive drugs are common antihypertensive drugs in clinical practice, such as valsartan, chlorosartan, irbesartan and so on. Such antihypertensive drugs have good efficacy in hypertensive patients with obesity, diabetes mellitus, cardiac and renal target organ damage. They are contraindicated in patients with hyperkalemia, pregnancy, and bilateral renal artery stenosis. Patients with blood creatinine over 3mg/dl should be used with caution. Sartan-type antihypertensive drugs should be taken under the guidance of a doctor, and if there is any discomfort in the course of taking the drug, a doctor should be consulted immediately.