If you wake up at two o’clock in the night and have difficulty falling asleep, you are said to be waking up prematurely. Early awakening is also one of the manifestations of insomnia and belongs to a kind of sleep disorder. Patients are often accompanied by depression, which is manifested by thinking about things more in general, worrying, being depressed, not being happy, feeling that there is nothing to be happy about, and also accompanied by obvious loss of interest, and not being able to bring up the energy to do things that they used to like to do now. In this case, it is generally recommended to visit a neurologist or psychiatrist to improve the anxiety and depression scales, and sleep monitoring and the Pittsburgh Sleepiness Scale if possible. After the diagnosis is clear, symptomatic treatment with drugs can be given, such as oral drugs to prolong the sleep phase, such as alprazolam; anti-anxiety and antidepressant treatment can also be given, such as duloxetine, escitalopram oxalate, paroxetine in the morning, and mirtazapine, agomelatine, trazodone at night.