Acne during physiological period is mainly due to hormone level disorders, can be eliminated through skin cleansing, ensure adequate sleep and improve diet, etc., and in serious cases, follow the doctor’s instructions to use medication. Due to the different conditions and personal constitution, there is no such thing as quick elimination. Acne during physiological period is related to the hormones in the body, during the female menstruation period, the body of estrogen decreases, androgen is relatively high, which will cause acne. Can through the skin cleaning, wash away excess oil, to avoid clogging pores, but also to ensure adequate sleep, avoid staying up late, diet to light, avoid spicy stimulation to help improve. Physiological period long acne generally do not need to use drugs, wait until after the physiological period, hormones return to normal levels, acne can be eliminated on their own, generally do not need to worry too much. The more serious or after the life conditioning still acne patients need medication, such as topical retinoids (adapalene gel, tazarotene gel), benzoyl peroxide, antibiotics (fusidic acid, mupirocin) and other drugs, if necessary, can also be combined with oral retinoids such as isotretinoin soft capsule, antibiotics such as doxycycline tablets and other medications. If the acne does not go away during the physiological period, it is recommended to go to the hospital in time, and the medication should be used according to the doctor’s instructions.